I found the following two guides that should be helpful to any Twitter user. I hope that you find them useful.
How To Bulk Remove Twitter Accounts From Your Follow List
You can find a few web tools to easily unfollow non-followers, unfollow a lot of people in a single step and a final crazy method that you gotta go read about it on MacLife.
How To Temporarily Silence Followers in Your Twitter Feed
Shows a method on muting users based on keywords that you don’t want to see.
To easy manage your Twitter followers and friends I highly recommend BirdBrain App, here’s an Arabic review on SaudiMac by Mohammad.
What are your favorite Twitter tools?